MicroRNAs (miRNAs, miRs) are small endogenous non-coding RNAs that regulate the expression of protein-encoding genes at the post-transcriptional level. Several studies have described the role of miRNAs in T-cell acute lymphoblastic leukemia (T-ALL), including tumor suppressor and oncogenic miRNAs. Down-regulation of miRNA expression is a prominent feature of human malignancy. This down-regulati...

intoduction: the discovery of micrornas (mirnas), an extensive family of small non-protein-coding rnas, provided an exciting era in cancer research and recent findings have prompted us to revise the traditional concept of cancer. deregulated mirnas   expression influences biological events leading to cancer such as proliferation, differentiation, metastasis and apoptosis. the expression of onco...

Resistance to cancer treatment is one of the major challenges currently faced when treating gastrointestinal (GI) cancers. A contributing factor this resistance presence stem cells (CSCs) in GI cancers (e.g., colorectal, pancreatic, gastric, liver cancer). Non-coding RNAs, such as microRNAs (miRNAs), have been found regulate several key targets that are responsible for stemness, and function on...

The genetic and epigenetic alteration was commonly related to the progression of breast cancer. Epigenetic which comprises DNA methylation microRNA is involved in controlling gene expression cancer cells. change cellular transformation, tumorigenesis, stemness marker were accomplished by this modification. short, non-coding RNAs, are called microRNAs (miRNAs) considered as a master regulator ge...

Background: Micro-Ribonocellic Acids (miRNA) are non-coding nucleic acids that are evolutionally protected and have a length of 24-20 nucleotides. MiRNAs control the expression of genes after transcription by mRNA degradation or translation inhibition. By blocking the oncogenic miRNAs and creating the necessary and functional miRNAs (tumor suppressor), these small regulatory RNAs can have thera...

MicroRNAs (miRNAs) represent a class of non-coding RNAs that exert pivotal roles in the regulation of gene expression at the post-transcriptional level. MiRNAs are involved in many biological processes and slight modulations in their expression have been correlated with the occurrence of different diseases. In particular, alterations in the expression of miRNAs with oncogenic or tumor suppresso...

Cancer is one of the leading causes death worldwide. Multifactorial etiology cancer and tumor heterogeneity are two most acute challenges in existing diagnostic therapeutic strategies for cancer. An effective precision medicine strategy to overcome these requires a clear understanding transcriptomic landscape cells. Recent innovative breakthroughs high-throughput sequencing technologies have id...

micrornas (mirnas) are non-coding small rna molecules with 21–25 nucleotides. it plays significant role in control of gene expression at posttranscriptional/translational level. they are commonly dysregulated in human cancers, whereas they may behave either as oncogenes or as tumor-suppressor genes. both genetic and epigenetic events in deregulation of mirna can lead to cancer development. gene...

micrornas are 19-22 nucleotide rnas involved in such important processes as development, proliferation, differentiation and apoptosis. different mirnas are uniquely expressed in lymphoid t cells, and play a role indevelopment and differentiation of various subtypes by targeting their target genes. recent studies have shown that aberrant mirna expression may be involved in t cell leukemogenesis ...

  Objective(s):Transforming growth factor-β(TGF-β) is involved in colorectal cancer (CRC). The SD-208 acts as an anti-cancer agent in different malignancies via TGF-β signaling. This work aims to show the effect of manipulation of TGF-β signaling on some miRNAs implicated in CRC. Materials and Methods: We investigated the effects of SD-208 on SW-48, a colon adenocarcinoma cell line. The cell li...